OpenCell: 3-in-1 DNA extraction device
Your new ‘lab-in-a-backpack’
The OpenCell device is constructed entirely from 3D-printed and off-the-shelf components at a unit cost of less than $50.
High-cost DNA extraction procedures pose significant challenges for budget-constrained laboratories.
Many labs face budget limitations that make DNA extraction a real headache. That’s why we created OpenCell. It’s a low-cost, easy-to-use, all-in-one gadget that replaces three core lab tools: a bead homogenizer, a microcentrifuge, and a vortex mixer.
High speed recording of OpenCell in action.
Major questions
1) Can we create an effective, open-sourced, low-cost, and accessible option for DNA extraction?
2) Is OpenCell simple enough to be used and assembled by any lab?
3) How does OpenCell compare to commercial devices?
What we’ve discovered
OpenCell costs less than $50 dollar to manufacture
Each component, from the filament options to the m3 fasteners, are made to ensure they can be printed by most consumer 3D printers, be easily assembled, and be accessible on a budget. It incorporates an array of safety features that also ensure it is user-friendly.
OpenCell streamlines the DNA extraction workflow
The DNA extraction process divides into four steps: lysis, binding, washing, and elution, each utilizing different OpenCell attachments. With its tool-less mounting mechanism and modular design, OpenCell can quickly switch functionality for the given task
OpenCell is comparable to commercial options
The OpenCell system consistently generates DNA extracts with both satisfactory yield and A260/A280 values well within the usable range, aligning our device’s performance with commercial protocols and equipment.
Read the paper
OpenCell: A Low-cost, Open-Source, 3-in-1 device for DNA Extraction. Plos ONE (2023)
Download the STL files and Arduino code to build your own OpenCell device.